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Principal Scientist, Novasenta


The successful candidate will provide day-to-day leadership for the target validation platform development efforts of Novasenta. Specifically, the successful candidate will design, develop and apply cutting-edge methods to accelerate target validation process for novel cancer immunotherapy development.


•Must be willing to work flexible hours as necessary, and work beyond 40hrs is likely to be required.
•Develop in-depth scientific knowledge in the area of research focus and contribute to the decision making on project direction.
•Provide scientific expertise and train/direct junior lab members in research techniques.
•Oversee the assay design and optimization efforts of junior lab members.
•Establish novel mechanistic insights addressing impact of novel target.
•Propose targets for experimental prosecution and design appropriate assays to validate each target and the biological hypothesis.
•Implement assays on a rolling basis to integrate platform learnings to increase sophistication of target validation.
•Lead efforts to develop and scale target validation scope and throughout over time.
•Works with and reports to the scientific founders and the Program Coordinator to investigate the most promising targets within the tumor microenvironment for the development of therapeutics.


-Ph.D. in immunology with 4+ years of post-doctoral experience in academia or industry, experience in immuno-oncology is required.

-Proven ability to successful drive and lead research projects.

-Demonstrated record of success with strong publication record.

-Demonstrated ability to effectively supervise, inspire, and develop research associates.

-Experience performing and analyzing a broad array of molecular, cellular biological and immunology methods.

-Experience in working under GLP standards (writing research reports, SOPs, and IND sections) and ensuring safety compliance under BSL-2 is a plus.

-Good verbal and written communication skills and the ability to interpret, summarize, and present scientific results in a clear, concise, accurate manner to both technical and non-technical audiences.

-Ability to deal with uncertainty and solve problems creatively and independently with solid judgement.

-The ideal candidate has demonstrated success in highly dynamic research and/or biotech setting.6+ years of experience post PhD, with preferably at least 2 years of experience in an industry setting preferred.

-Experience advancing assets from target discovery through validation preferred.

-Experience collaborating with computational teams preferred.

Licensure, Certifications, and Clearances:

UPMC is an Equal Opportunity Employer/Disability/Veteran

Location: Pittsburgh, PA, United States
Job ID: 879392047

UPMC is an equal opportunity employer.
Minority / Females / Veterans / Individuals with Disabilities