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Research Scientist, TTMS

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Drives cancer immunology research efforts, designs and executes genomic screening and editing studies to support therapy development efforts of TTMS Inc., a UPMC Enterprises funded biotech startup focused on developing new cancer therapies targeting immunoregulatory mechanisms in the tumor microenvironment, reporting to the Program Coordinator.


  • Must be willing to work flexible hours as necessary, and work beyond 40hrs is likely to be required
  • Supervises junior lab members
  • Actively participates in the scientific dialogue of the group and proactively collaborates with colleagues
  • Independently designs, performs and analyzes assays involving in vitro, in vivo and ex vivo testing of therapeutic target development
  • Develops molecular and cell-based assays for testing gene editing tools and sgRNAs
  • Supports the company leadership and the Program Coordinator in establishing genomic screening and editing platform
  • Supports the Program Coordinator in genomic screening and editing efforts for target-related studies that include library-based genome-wide screening, arrayed CRISPR/shRNA screen, CRISPR/shRNA-based target assessment
  • Works with and reports to the scientific founders and the Program Coordinator to investigate the most promising targets within the tumor microenvironment for the development of therapeutics






  • Ph.D. in immunology with 3+ years of post-doctoral experience in a biotechnology or pharmaceutical setting
  • Experience in library-based genome-wide screens using CRISPR/Cas9-based gene editing is required
  • Expertise in designing the screen strategy and analyzing the readout
  • Good understanding in bioinformatic tools and experience working closely with bioinformatic expert
  • Expertise in high throughput screening, cloning, and advanced molecular biology is strongly preferred
  • Experience in flow cytometry and other analytical techniques (e.g. qPCR)Significant experience in immuno-oncology-related animal studies is required Experience in genomic screening using tumor models is highly desired
  • Experience in working under GLP standards (writing research reports, SOPs, and IND sections) and ensuring safety compliance under BSL-2 is a plus
  • Good verbal and written communication skills and the ability to interpret, summarize, and present scientific results in a clear, concise, accurate manner to both technical and non-technical audiences
  • Ability to deal with uncertainty and solve problems creatively and independently with solid judgement
  • The ideal candidate has demonstrated success in highly dynamic research and/or biotech setting









    Location: Pittsburgh, PA, United States
    Job ID: 41155257

    UPMC is an equal opportunity employer.
    Minority / Females / Veterans / Individuals with Disabilities