Sorry, we’re not accepting applications for this job right now. But don’t go yet! Explore our site
to find more opportunities to join us in transforming the future of health care.
Drives cancer immunology research efforts, designs and executes genomic screening and editing studies to support therapy development efforts of TTMS Inc., a UPMC Enterprises funded biotech startup focused on developing new cancer therapies targeting immunoregulatory mechanisms in the tumor microenvironment, reporting to the Program Coordinator.
- Must be willing to work flexible hours as necessary, and work beyond 40hrs is likely to be required
- Supervises junior lab members
- Actively participates in the scientific dialogue of the group and proactively collaborates with colleagues
- Independently designs, performs and analyzes assays involving in vitro, in vivo and ex vivo testing of therapeutic target development
- Develops molecular and cell-based assays for testing gene editing tools and sgRNAs
- Supports the company leadership and the Program Coordinator in establishing genomic screening and editing platform
- Supports the Program Coordinator in genomic screening and editing efforts for target-related studies that include library-based genome-wide screening, arrayed CRISPR/shRNA screen, CRISPR/shRNA-based target assessment
- Works with and reports to the scientific founders and the Program Coordinator to investigate the most promising targets within the tumor microenvironment for the development of therapeutics
Experience in library-based genome-wide screens using CRISPR/Cas9-based gene editing is requiredExpertise in designing the screen strategy and analyzing the readoutGood understanding in bioinformatic tools and experience working closely with bioinformatic expertExpertise in high throughput screening, cloning, and advanced molecular biology is strongly preferredExperience in flow cytometry and other analytical techniques (e.g. qPCR)Significant experience in immuno-oncology-related animal studies is required Experience in genomic screening using tumor models is highly desiredExperience in working under GLP standards (writing research reports, SOPs, and IND sections) and ensuring safety compliance under BSL-2 is a plusGood verbal and written communication skills and the ability to interpret, summarize, and present scientific results in a clear, concise, accurate manner to both technical and non-technical audiencesAbility to deal with uncertainty and solve problems creatively and independently with solid judgementThe ideal candidate has demonstrated success in highly dynamic research and/or biotech setting